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Tackling the world's population health challenges through research, education and collaboration.

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70 trials, few answers: the case for better research on interventions for depression among patients with cancer

Maria Pertl, Katie Verling, Garret Monahan and Frank Doyle Depression is common among people living with and beyond cancer, and can hugely impact on quality of life, as well as health outcomes. Yet, despite decades of research, we still don’t know which treatments for depression work best. Our recent review, published in the Journal of Psychosomatic Research , set out to answer this question by comparing the effectiveness of all available intervention approaches for depression in adults with cancer. What we found was both revealing and concerning. A comprehensive review with a twist We reviewed 70 randomised controlled trials (RCTs), that included over 6,800 participants and a wide range of intervention approaches – from psychotherapy and pharmacotherapy to exercise, complementary therapies, and collaborative care. Our goal was to use a network meta-analysis (NMA) to compare the effectiveness and acceptability of these treatments. The quality problem Most of the trials we reviewe...

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